As the Zopisign 7.5 (Zopiclone) Tablet is removed through hepatic metabolism, hepatic impairment raises the possibility of side effects. After a single dose, zopiclone's elimination half-life in healthy individuals is 5 hours. The elimination half-life is increased in hepatic failing patients to almost 12 hours. 7.5 mg is the dosage that is advised for senior people. If the lower dose is ineffective, the dose may be increased; nevertheless, a greater amount is more likely to have adverse effects on the elderly's central nervous system.

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